Longevity & aging

CJC-1295 (No DAC)

A synthetic analogue of growth hormone releasing hormone (GHRH 1-29).

About

CJC-1295 without DAC — also referred to as modified GRF (1-29) — is a synthetic analogue of the first 29 amino acids of growth hormone releasing hormone, the fragment that carries the receptor-binding activity of the full hormone. Amino acid substitutions in the sequence are intended to slow enzymatic degradation relative to native GHRH. The "with DAC" variant is a different molecule with a substantially different half-life.

Mechanism

The peptide binds the growth hormone releasing hormone receptor on somatotroph cells of the anterior pituitary. Receptor binding is associated in the literature with pulsatile release of endogenous growth hormone, in contrast to administration of growth hormone itself. Because release remains subject to normal feedback from somatostatin, the resulting pattern is described as preserving physiological pulsatility. Substitutions at positions in the native sequence reduce cleavage by dipeptidyl peptidase-4.

What research has examined

Research has examined GHRH analogues in endocrinology, principally in the context of growth hormone secretion dynamics and pituitary function.