Metabolic & weight
5-Amino-1MQ
A small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase.
About
5-Amino-1-methylquinolinium is a small molecule, not a peptide, studied as an inhibitor of nicotinamide N-methyltransferase (NNMT). It appears in metabolic and longevity research because of the position that enzyme occupies in NAD+ handling. It is included in this catalogue for that reason rather than as a peptide.
Mechanism
NNMT catalyses the methylation of nicotinamide, diverting it away from the salvage pathway that regenerates NAD+. Inhibiting the enzyme is described in the literature as preserving nicotinamide for that pathway, with reported downstream effects on intracellular NAD+ concentration and on sirtuin activity. Published work in adipose tissue models associates NNMT inhibition with changes in cellular energy expenditure. This is an actively developing research area and the mechanistic account should be read as provisional.
What research has examined
Studies have investigated NNMT inhibition in adipocyte culture and in rodent models of diet-induced obesity.
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